Effects of Medetomidine, Dexmedetomidine and ... - Publons

Effects of Medetomidine, Dexmedetomidine and their combination with Acepromazine on the intraocular pressure (IOP), tear secretion and pupil ... DownloadWebofScience™MyResearchAssistant: BringthepoweroftheWebofSciencetoyourmobiledevice,wherever inspirationstrikes. HomePublicationsPublicationDetailsEffectsofMedetomidine,DexmedetomidineandtheircombinationwithAcepromazineontheintraocularpressure(IOP),tearsecretionandpupildiameterindogsReviewbadges 3pre-pubreviews  0post-pubreviews Identifierspublons.com/p/42229960/doi.org/10.1002/VMS3.467pubmed.ncbi.nlm.nih.gov/33751831NavigateAbstractContributorsMetricsPeerreviewPre-publicationreview(finalround) Decisionletter,Feb2021 Reviewerreport,Jan2021 Authorresponse,Dec2020 Pre-publicationreview(round2) Decisionletter,Dec2020 Reviewerreport,Nov2020 Reviewerreport,Oct2020 Pre-publicationreview(round1) Decisionletter,Jul2020 PublicationHistoryMar2021inVeterinaryMedicineandScience EffectsofMedetomidine,DexmedetomidineandtheircombinationwithAcepromazineontheintraocularpressure(IOP),tearsecretionandpupildiameterindogs Publishedin VeterinaryMedicineandScience onMarch10,2021 WebofScience(FreeAccess) Viewfullbibliographicrecord Viewcitingarticles AbstractBackground:Agreatnumberofsedativesandanaestheticshavebeenusedtoperformsurgeriesorroutineophthalmologicexaminationsinanimalsandsometimesthecombinationofthesemedicineshasmoresuitableeffectsthaneachonealone.Objectives:ThispaperaimstoexplorethemaineffectsofMedetomidine+Acepromazine,Dexmedetomidine+Acepromazineonintraocularpressure,tearsecretionandpupildiameter.Methods:Toaccomplishtheaforementionedaim,32adultdogs(agedone-to-three-years-old)wereclinicallyexamined.DogsweredividedintofourgroupsconsistingofgroupDA,Dexmedetomidine(5mug/kg)+Acepromazine(0.05mg/kg);GroupD,Dexmedetomidine(5mug/kg);GroupM,Medetomidine(10mug/kg);GroupMA,Medetomidine(10mug/kg)+Acepromazine(0.05mg/kg).Theocularfactorsincludingtearproduction,pupildiameterandintraocularpressureofbothrightandlefteyeswerefirstmeasuredandthenrecordedineachdogattimeT-0(-15min).Afterwards,thedrugswereadministeredintramuscularly,basedonwhichtheocularfactorswerere-measuredatT-1(+5min),T-2(+15min)andT-3(+20min).Allfourgroupsshowedareductioninintraocularpressure,whichwassignificantinDA,DandMgroups.Results:Furthermore,therewasafluctuationintheamountoftearsecretioninDAandDgroups(increaseandthendecrease),aswellasasignificantreductioninMandMAgroups.Decreasinginpupildiameteralsooccurredinallfourgroups,butthereductionwassignificantonlyinDAandMAgroups.Conclusion:Accordingtotheresultsobtained,asthechangescausedbythesystemicadministrationoftheabovedrugcompoundsdidnotexceedthephysiologicalrange,itcanbeconcludedthatthesecombinationscouldbeutilizedassuitablesedativesorpre-anaestheticcompoundsintheeyesurgeries. READARTICLEONJOURNALWEBSITE Authors Aghababaei,Ali;  Ronagh,Ali;  Mosallanejad,Bahman;  Baniadam,Ali Publonsuserswho'veclaimed -Iamanauthor NoPublonsusershaveclaimedthispaper.ContributorsonPublons1reviewerMetricsPublonsscore(from0scores) ? AltmetricWebofScienceCoreCollectionCitations 1ScorepublicationAddreview16-Feb-2021DearDr.Ronagh:Itisapleasuretoacceptyourmanuscriptentitled"EffectsofMedetomidine,DexmedetomidineandtheirCombinationwithAcepromazineontheIntraocularPressure(IOP),TearSecretion,andPupilDiameterinDogs"initscurrentformforpublicationinVeterinaryMedicineandScience.Pleasenotealthoughthemanuscriptisacceptedthefileswillnowbecheckedtoensurethateverythingisreadyforpublication,andyoumaybecontactediffinalversionsoffilesforpublicationarerequired.Thefinalversionofyourarticlecannotbepublisheduntilthepublisherhasreceivedtheappropriatesignedlicenseagreement.OnceyourarticlehasbeenreceivedbyWileyforproductionthecorrespondingauthorwillreceiveanemailfromWiley’sAuthorServicessystemwhichwillaskthemtologinandwillpresentthemwiththeappropriatelicenseforcompletion.PaymentofyourOpenAccessArticlePublicationCharge(APC): AllarticlespublishedinVeterinaryMedicineandSciencearefullyopenaccess:immediatelyandfreelyavailabletoread,downloadandshare.VeterinaryMedicineandSciencechargesanarticlepublicationcharge(APC).Beforewecanpublishyourarticle,yourpaymentmustbecompleted.ThecorrespondingauthorforthismanuscriptwillhavealreadyreceivedaquoteemailshortlyafteroriginalsubmissionwiththeestimatedArticlePublicationCharge;pleaseletusknowifthishasnotbeenreceived.Onceyouracceptedpaperisinproduction,thecorrespondingauthorwillreceiveane-mailinvitingthemtoregisterwithorlogintoWileyAuthorServices(www.wileyauthors.com)wherethepublicationfeecanbepaidbycreditcard,oraninvoiceorproformacanberequested.Theoptiontopayviacreditcardandclaimreimbursementfromyourinstitutionmayhelptoavoiddelayswithpaymentprocessing.Thankyouforyourfinecontribution.OnbehalfoftheEditorsofVeterinaryMedicineandScience,welookforwardtoyourcontinuedcontributionstotheJournal.Sincerely, Prof.GayleHallowell EditorinChief,VeterinaryMedicineandScience [email protected].–Youcanhelpyourresearchgettheattentionitdeserves!WileyEditingServicesoffersprofessionalvideoabstractandinfographiccreationtohelpyoupromoteyourresearchatwww.wileyauthors.com/eeo/promotion.And,checkoutWiley’sfreePromotionGuideforbest-practicerecommendationsforpromotingyourworkatwww.wileyauthors.com/eeo/guide.ThisjournalacceptsartworksubmissionsforCoverImages.Thisisanoptionalserviceyoucanusetohelpincreasearticleexposureandshowcaseyourresearch.Formoreinformation,includingartworkguidelines,pricing,andsubmissiondetails,pleasevisittheJournalCoverImagepageatwww.wileyauthors.com/eeo/covers.AssociateEditorCommentstoAuthor:Reviewer(s)'CommentstoAuthor:Reviewer:3CommentstotheAuthor Welldone,howeveripreferEnglisheditingoncemore.DecisionletterbyGayleHallowellCitethisdecisionletterWelldone,howeveripreferEnglisheditingoncemore.ReviewedbyAnonymousCitethisreviewThereviewerthankedforreviewingthisarticle.Responsestoreviewers:Reviewer:1Responsetoreviewer1ismarkedingreeninthemanuscript.1)CanIsuggestthatyoufindanophthalmologistwithEnglishastheirfirstlanguagetoaidinimprovingthelanguageusedinthepaper?Iwouldbehappytoreassessthepaperwhenthishashappened. Author`sresponse:AlthoughitwasnotpossibletofindanEnglish-speakingophthalmologist,allpartsofthearticlewerereviewedbyanativeEnglish-speakertranslator.2)Mykeyconcernthoughiswhythesedogswerehavingthedrugs.Ifitonlyforthisstudycanthisbejustifiedethically-itcouldnotbeinmyvetschoolintheUK. Author`sresponse:Whilethankingthereviewerfortheconcernabouttheethicalissue,itshouldbenotedthatthemethodofthepresentstudyisnotintensiveanddoesnotcauseanyharmtotheanimals.3)Iamalsosadthatthestudywasonlycarriedoutfor20minutes.IfthedogswerethenanaesthetisedforaprocedurethiswouldbeOK,butifnotitwouldhavebeenofinteresttoknowwhathappensasthesedationwearsoff. Author`sresponse:Areviewersuggestedevaluatingoculareffectsinalongerperiodaftersedationespeciallywhenthesedationwearsoff,Ihavetosayitwoulddefinitelybebetterbutincaseofethicalaffairwemadethisperiodshort.Also,theaimofthisstudywastofindasuitabledrugcombinationthathasbothsedationandanalgesicpropertiesandthatcouldbeusedincaseswheretheanimalneedssedationforeyeexaminations.Besides,eyeexaminationsusuallydonottakemorethan20minutesandthereforethistimewasconsideredtoevaluatetheoculareffectsofthiscombination.ResponsetoReviewer:2Responsetoreviewer2ismarkedinyellowinthemanuscript.Whilethankingareviewerforsuggestions,therequestedpartsofthearticlebyreviewer2areeditedandmarkedinyellow.1)IsuggestrewritingtheBackground? Author`sresponse:Ithasbeenrewrittenagain.2)movingthesentence(ThispaperaimstoexplorethemaineffectsofMedetomidine+Acepromazine,Dexmedetomidine+Acepromazineonintraocularpressure,tearsecretionandpupildiameter)andputininobjectives. Author`sresponse:Itwasdone.3)Move8-12linesandputinmaterialandmethods. Author`sresponse:Itwasdone.4)ThestudywasapprovedbytheReviewBoardforAnimalsCare?Consentobtainedwasverbal,astheclinicalstudy?wasperformedonpatientswhoneededintraophythalmicsurgery? Author`sresponse:Thedogsusedinthisstudywerehealthyanddidnotundergoanyeyesurgery.ForthisstudythesedogsweretakenfromthedogshelterinAhvaz.ItshouldalsobenotedthattheprojectwasapprovedbythelocalCommitteeoftheInstitutionalAnimalCareandUseof(no.).5-Haveyouobtainedinformedconsentfromtheowners? Author`sresponse:Shelterofficialswereawareofthestudyprocessandbecausethemethodofthepresentstudyisnotaggressiveanddoesnotcauseanyharmtotheanimalstheyagreedtoit.6-Insertandcommentonthefollowingbibliography: 1.InterlandiC,CalapaiG,NastasiBetal.Effectsofatipamezoleontheanalgesicactivityofbutorphanolinrats.JournalofExoticPetMedicine.2017;4:290-293. 2.LeonardiF,CostaGL,StagnoliAetal.Theeffectofintramusculardexmedetomidine-butorphanolcombinationontearproductionindogs.CanadianVeterinaryJournal(Inpress). 3.DiPietroS,MacrìF,BonarrigoT,GiudiceE,PalumboPiccionelloA,PuglieseA.Effectsofamedetomidine-ketaminecombinationonSchirmerteartestIresultsofclinicallynormalcats.AmericanJournalofVeterinaryResearch.2016;77:310-4. 4.LeonardiF,CostaGL,DubauM,SabbioniA,SimonazziB,AngeloneM.Effectsofintravenousromifidine,detomidine,detomidinecombinedwithbutorphanol,andxylazineontearproductioninhorses.EquineVeterinaryEducation2020;32:53-57 Author`sresponse:Suggestedarticleswereusedandinsertedintheneweditionofthisarticle.Authorresponseby Aghababaei,Ali Ronagh,Ali Mosallanejad,Bahman Baniadam,Ali Citethisauthorresponse01-Dec-2020DearDr.Ronagh:ManuscriptIDVMS3-2020-Sep-0432entitled"EffectsofMedetomidine,DexmedetomidineandtheirCombinationwithAcepromazineontheIntraocularPressure(IOP),TearSecretion,andPupilDiameterinDogs"whichyousubmittedtoVeterinaryMedicineandScience,hasbeenreviewed.Iwillbehappytoacceptyourpaperpendingminorrevisions.Iinviteyoutorespondtothecommentsappendedbelowandreviseyourmanuscript.Beforesubmittingyourrevisions:Preparearesponsetothereviewercommentsappendedbelowinpoint-by-pointfashion.Inordertoexpeditetheprocessingoftherevisedmanuscript,pleasebeasspecificaspossibleinyourresponseandindicatethepagenumbersinthemanuscriptwhereyouhaveaddressedeachcomment.Preparearevisedmanuscript(worddocument),highlightingthechangesyou’vemade.Savethisnewdocumentonyourcomputerasyouwillbeaskedtouploaditduringtherevisionsubmissionprocess.NOTE:Pleasebesuretokeepinmindreviewercommentsandincorporateyourresponseswithinthemanuscript.Theremaywellbeareaswhereyoudisagree;forexample,youmaywanttowrite,"Areviewersuggeststhat...However,Idisagreebecause...".Inanycase,pleasetrytoaddressalloftheconcernsthatareraisedwithinthemanuscript.Inadditiontoyourrevisedmanuscriptwithchangeshighlighted,pleasealsosavea“clean”copywherethechangesarenotmarked.AuthorContributionIndication Thecontributionsofeachauthortothisworkmustnowbeindicatedwhenyousubmityourrevisedmanuscript.ToaddAuthorContributionsusingCRediTtaxonomy(https://casrai.org/credit/),simplyclickthe“ProvideCRediTContribution”linkforeachauthorinthe‘Authors&Institutions’stepofthesubmissionprocess.Fromthere,youwillbeabletocheckapplicableAuthor/ContributorRolesand,ifavailable,specifytheDegreeofContribution.YouMUSTprovidethisinformationaspartoftherevisionprocess.AuthorContributionswillbepublishedwiththeacceptedarticleandcannotbeeditedafterarticleacceptance.ThereforeyoumustensuretheAuthorContributioninformationyouprovideisaccuratepriortofinalacceptance.Tosubmityourrevisedmanuscript:LoginbyclickingonthelinkbelowPLEASENOTE:Thisisatwo-stepprocess.Afterclickingonthelink,youwillbedirectedtoawebpagetoconfirm.https://mc.manuscriptcentral.com/vetmedsci?URL_MASK=0018e39804ba49029f9d8ce93e89d3b7ORLogintohttps://mc.manuscriptcentral.com/vetmedsciandclickonAuthorCenter.Underauthorresources,usethebutton“Clickheretosubmitarevision”.PLEASEDONOTSUBMITYOURREVISIONSASANEWMANUSCRIPT.Followtheon-screeninstructions.Firstyouwillbeaskedtoprovideyour“ResponsetoDecisionLetter”—thisistheresponsetoreviewercommentsthatyoupreparedearlier.Clickthroughthenextfewscreenstoverifythatallpreviouslyprovidedinformationiscorrect.FileUpload:Deleteanyfilesthatyouwillbereplacing(thisincludesyouroldmanuscript).Uploadyournewrevisedmanuscriptfilewithchangeshighlighted,a“clean”copyofyourrevisedmanuscriptfile,anyreplacementfigures/tables,oranynewfiles.Oncethisiscomplete,thelistoffilesinthe“MyFiles”sectionshouldONLYcontainthefinalversionsofeverything.REMEMBER:figures/tablesshouldbeinjpeg,tiff,orepsformat.Ifyouhaven'tdonesoalready,pleaseconsideruploadinganimageoftheorganism(s)studiedinyourpapertobeconsideredforonlinecoverandblogpublication.Reviewandsubmit:pleasebesuretodouble-checkeverythingcarefullysothatyourmanuscriptcanbeprocessedasquicklyaspossible.Deadlines: BecausewearetryingtofacilitatetimelypublicationofmanuscriptssubmittedtoVeterinaryMedicineandScience,yourrevisedmanuscriptshouldbeuploadedassoonaspossible.Ifitisnotpossibleforyoutosubmityourrevisionin30days,wemayhavetoconsideryourpaperasanewsubmission.Ifyoufeelthatyouwillbeunabletosubmityourrevisionwithinthetimeallowedpleasecontactmetodiscussthepossibilityofextendingtherevisiontime.WileyEditingServicesAvailabletoAllAuthors Shouldyoubeinterested,WileyEditingServicesoffersexperthelpwithmanuscript,language,andformatediting,alongwithotherarticlepreparationservices.Youcanlearnmoreaboutthisserviceoptionatwww.wileyauthors.com/eeo/preparation.YoucanalsocheckoutWiley’scollectionoffreearticlepreparationresourcesforgeneralguidanceaboutwritingandpreparingyourmanuscriptatwww.wileyauthors.com/eeo/prepresources.IfyoupreviouslyoptedinforTransparentPeerReviewpleasenotethatyourresponsetothereviewerswillbepublishedaspartofthefullreviewhistoryofyourpaper.Onceagain,thankyouforsubmittingyourmanuscripttoVeterinaryMedicineandScienceandIlookforwardtoreceivingyourrevision.Sincerely, Prof.GayleHallowell EditorinChief,VeterinaryMedicineandScience [email protected]:AssociateEditor CommentstotheAuthor: ThankyouforsubmittingyourmanuscripttoVeterinaryMedicineandScience.Asyoucanseefromthecommentsattached,thereviewershaverecommendedrevisionstoyourmanuscript.Ifthemanuscriptcanberevisedtosatisfytheseconcerns,wewouldbehappytoreevaluateit.Reviewer(s)'CommentstoAuthor:Reviewer:1CommentstotheAuthor Theauthorsarethankedforthismanuscript.CanIsuggestthatyoufindanophthalmologistwithEnglishastheirfirstlanguagetoaidinimprovingthelanguageusedinthepaper?Iwouldbehappytoreassessthepaperwhenthishashappened. Mykeyconcernthoughiswhythesedogswerehavingthedrugs.Ifitonlyforthisstudycanthisbejustifiedethically-itcouldnotbeinmyvetschoolintheUK. Iamalsosadthatthestudywasonlycarriedoutfor20minutes.IfthedogswerethenanaesthetisedforaprocedurethiswouldbeOK,butifnotitwouldhavebeenofinteresttoknowwhathappensasthesedationwearsoff.Reviewer:2CommentstotheAuthor ABSTRACT theAbstract(Summary)clearlyandaccuratelydescribethecontentofthearticle. However,IsuggestrewritingtheBackground,movingthesentence(ThispaperaimstoexplorethemaineffectsofMedetomidine+Acepromazine,Dexmedetomidine+Acepromazineonintraocularpressure,tearsecretionandpupildiameter)andputininobjectives.Move8-12linesandputinmaterialandmethods. MATERIALSANDMETHODS ThestudywasapprovedbytheReviewBoardforAnimalsCare?Consentobtainedwasverbal,astheclinicalstudy?wasperformedonpatientswhoneededintraophythalmicsurgery? Haveyouobtainedinformedconsentfromtheowners? Whatwerethereasonsforexclusionfromthestudy DISCUSSIONInsertandcommentonthefollowingbibliography: 1.InterlandiC,CalapaiG,NastasiBetal.Effectsofatipamezoleontheanalgesicactivityofbutorphanolinrats.JournalofExoticPetMedicine.2017;4:290-293. 2.LeonardiF,CostaGL,StagnoliAetal.Theeffectofintramusculardexmedetomidine-butorphanolcombinationontearproductionindogs.CanadianVeterinaryJournal(Inpress). 3.DiPietroS,MacrìF,BonarrigoT,GiudiceE,PalumboPiccionelloA,PuglieseA.Effectsofamedetomidine-ketaminecombinationonSchirmerteartestIresultsofclinicallynormalcats.AmericanJournalofVeterinaryResearch.2016;77:310-4. 4.LeonardiF,CostaGL,DubauM,SabbioniA,SimonazziB,AngeloneM.Effectsofintravenousromifidine,detomidine,detomidinecombinedwithbutorphanol,andxylazineontearproductioninhorses.EquineVeterinaryEducation2020;32:53-57DecisionletterbyGayleHallowellCitethisdecisionletterABSTRACT theAbstract(Summary)clearlyandaccuratelydescribethecontentofthearticle. However,IsuggestrewritingtheBackground,movingthesentence(ThispaperaimstoexplorethemaineffectsofMedetomidine+Acepromazine,Dexmedetomidine+Acepromazineonintraocularpressure,tearsecretionandpupildiameter)andputininobjectives.Move8-12linesandputinmaterialandmethods. MATERIALSANDMETHODS ThestudywasapprovedbytheReviewBoardforAnimalsCare?Consentobtainedwasverbal,astheclinicalstudy?wasperformedonpatientswhoneededintraophythalmicsurgery? Haveyouobtainedinformedconsentfromtheowners? Whatwerethereasonsforexclusionfromthestudy DISCUSSIONInsertandcommentonthefollowingbibliography: 1.InterlandiC,CalapaiG,NastasiBetal.Effectsofatipamezoleontheanalgesicactivityofbutorphanolinrats.JournalofExoticPetMedicine.2017;4:290-293. 2.LeonardiF,CostaGL,StagnoliAetal.Theeffectofintramusculardexmedetomidine-butorphanolcombinationontearproductionindogs.CanadianVeterinaryJournal(Inpress). 3.DiPietroS,MacrìF,BonarrigoT,GiudiceE,PalumboPiccionelloA,PuglieseA.Effectsofamedetomidine-ketaminecombinationonSchirmerteartestIresultsofclinicallynormalcats.AmericanJournalofVeterinaryResearch.2016;77:310-4. 4.LeonardiF,CostaGL,DubauM,SabbioniA,SimonazziB,AngeloneM.Effectsofintravenousromifidine,detomidine,detomidinecombinedwithbutorphanol,andxylazineontearproductioninhorses.EquineVeterinaryEducation2020;32:53-57ReviewedbyGiovannaLucreziaCostaCitethisreviewTheauthorsarethankedforthismanuscript.CanIsuggestthatyoufindanophthalmologistwithEnglishastheirfirstlanguagetoaidinimprovingthelanguageusedinthepaper?Iwouldbehappytoreassessthepaperwhenthishashappened. Mykeyconcernthoughiswhythesedogswerehavingthedrugs.Ifitonlyforthisstudycanthisbejustifiedethically-itcouldnotbeinmyvetschoolintheUK. Iamalsosadthatthestudywasonlycarriedoutfor20minutes.IfthedogswerethenanaesthetisedforaprocedurethiswouldbeOK,butifnotitwouldhavebeenofinteresttoknowwhathappensasthesedationwearsoff.ReviewedbyAnonymousCitethisreview20-Jul-2020DearDr.Ronagh:Iwritetoyouregardingmanuscript#VMS3-2020-Jul-0294entitled"EffectsofMedetomidine,DexmedetomidineandtheirCombinationwithAcepromazineontheIntraocularPressure(IOP),TearSecretion,andPupilDiameterinDogs"whichyousubmittedtoVeterinaryMedicineandScience.Theeditorialteamhasexaminedyourmanuscript,andIamsorrytosaywehavedecidedthatitdoesnotmeetourcriteriaforsendingitouttoreviewers.Inthiscasethisisbecausethelanguageofthecurrentversionwouldnotallowthereviewerstoevaluatethepaper'scontentinathoroughmanner.However,weinviteyoutoconsidersubstantiallyrevisingyourmanuscriptandre-submittingitasanewpaper.Giventhescopeofchangeswearesuggesting,thisnewmanuscriptwillbetreatedasanewsubmission.Youhave120daystomakethechanges.Whenyouresubmit,pleasequotetheoriginalreferencenumberandtitleinyourcoveringletter.IfyouwouldlikehelpwithEnglishlanguageediting,orotherarticlepreparationsupport,WileyEditingServicesoffersexperthelpwithEnglishLanguageEditing,aswellastranslation,manuscriptformatting,andfigureformattingatwww.wileyauthors.com/eeo/preparation.YoucanalsocheckoutourresourcesforPreparingYourArticleforgeneralguidanceaboutwritingandpreparingyourmanuscriptatwww.wileyauthors.com/eeo/prepresources.Sincerely, Prof.GayleHallowell EditorinChief,VeterinaryMedicineandScience gayle.hallowell@nottingham.ac.ukDecisionletterbyGayleHallowellCitethisdecisionletter AllpeerreviewcontentdisplayedhereiscoveredbyaCreativeCommonsCCBY4.0license. SendQuestionsSendReviewsClarivateblogResearchersCOVID-19indexPublicationsJournalsInstitutionsAPIOurMissionInthePressLogosTerms,Policies&GuidelinesHomeLoginRegisterActionsRegisterLearntoreviewBrowseResearchersJournalsPublicationsInstitutionsCountries/RegionsCommunityAcademy-LearntoreviewPeerViewsAwardsAdvanceyourcareerClarivateblogFAQFAQhomepageForReviewersForEditorsForAuthorsForPublishersForWebofScienceAcademy