Dexmedetomidine Dosage Guide + Max Dose, Adjustments

Procedural Sedation: -Initial Dose (including Awake Fiberoptic Intubation): 1 mcg/kg IV infusion over 10 minutes. -Maintenance Dose: Initiate IV ... Skiptomaincontent Close Treatments Sedation Dexmedetomidine Dosage Print Save DexmedetomidineDosageMedicallyreviewedbyDrugs.com.LastupdatedonOct30,2020. Appliestothefollowingstrengths:100mcg/mL;4mcg/mL-NaCl0.9%;4mcg/mL-D5% UsualAdultDosefor: Sedation UsualGeriatricDosefor: Sedation Additionaldosageinformation: RenalDoseAdjustments LiverDoseAdjustments DoseAdjustments Precautions Dialysis OtherComments UsualAdultDoseforSedation IntensiveCareUnitSedation: -InitialDose:Loadingdoseof1mcg/kgIVinfusionover10minutes. -MaintenanceDose:0.2to0.7mcg/kg/hourIVinfusion;adjusttheinfusionratetoachievethedesiredclinicaleffect. ProceduralSedation: -InitialDose(includingAwakeFiberopticIntubation):1mcg/kgIVinfusionover10minutes. -MaintenanceDose:InitiateIVinfusionat0.6mcg/kg/hourandtitratetoachievethedesiredclinicaleffect;dosesmayrangefrom0.2to1mcg/kg/hour. Uses:Sedationofinitiallyintubatedandmechanicallyventilatedpatientsduringtreatmentinanintensivecaresetting;sedationofnon-intubatedpatientspriortoand/orduringsurgicalandotherprocedures. UsualGeriatricDoseforSedation OverAge65Years: IntensiveCareUnitSedation:Dosereductionmayberequired;however,nospecificguidelineshavebeensuggested. ProceduralSedation: -InitialDose:Maybeomittedorreduced(e.g.,0.5mcg/kgIVinfusionover10minutes). -MaintenanceDose:Dosereductionmayberequired;however,nospecificguidelineshavebeensuggested. Uses:Sedationofinitiallyintubatedandmechanicallyventilatedpatientsduringtreatmentinanintensivecaresetting;sedationofnon-intubatedpatientspriortoand/orduringsurgicalandotherprocedures. RenalDoseAdjustments Datanotavailable. LiverDoseAdjustments Dosereductionmayberequired;however,nospecificguidelineshavebeensuggested. DoseAdjustments -IntensiveCareUnitSedation:Aloadingdosemaynotberequiredforpatientsbeingconvertedfromalternatesedativetherapy. -ProceduralSedationInitialDose:0.5mcg/kgIVinfusiongivenover10minutesmaybesuitableforlessinvasiveprocedures(e.g.,ophthalmicsurgery). -MaintenanceDoseforAwakeFiberopticIntubation:0.7mcg/kg/hourIVinfusionuntiltheendotrachealtubeissecured. -ConcomitantUsewithotherAnesthetics,Sedatives,Hypnotics,orOpioids:Dosereductionmayberequired;however,nospecificguidelineshavebeensuggested. Precautions Safetyandefficacyhavenotbeenestablishedinpatientsyoungerthan18years. ConsultWARNINGSsectionforadditionalprecautions. Dialysis Datanotavailable. OtherComments AdministrationAdvice: -Individualizedosing. -Administerusingacontrolledinfusiondevice. -Administrationbycontinuousinfusionshouldnotexceed24hours. -Performregularassessmentsifthisdrugisusedformorethan14days. -Considerlubricatingpatients'eyesduringdrugadministrationtoavoidcornealdrynesscausedbydrug-relatedlacrimationreduction. -Itisnotnecessarytodiscontinuethisdrugpriortoextubation. -Useadministrationcomponentsmadewithsyntheticorcoatednaturalrubbergasketssincethereispotentialforabsorptionofthisdrugtosometypesofnaturalrubber. Reconstitution/PreparationTechniques: -Consultthemanufacturerproductinformation. IVCompatibility: -Consultthemanufacturerproductinformation. General: -Inadditiontoitssedativeeffects,thisdrughasasympatholyticeffect,analgesicandanesthetic/analgesic-sparingeffects. -Avoidusingthisdrugasaninductionagentforintubationorforsedationduringmusclerelaxantuse. -Avoidusingthisdrugforobstetrics,includingcaesareansectiondeliveries,asthesafetyofthisdruginlaboranddeliveryhasnotbeenstudied. -Thisdrugisnotsuitableinpatientswhorequirecontinuousdeepsedationorwithseverecardiovascularinstability. -Thisdrughasnotbeenshowntobeamnestic. Monitoring: -ContinuouslymonitorECG,bloodpressure,heartrate,andoxygensaturationlevelsduringinfusionandafterwardsasclinicallyappropriate. Moreaboutdexmedetomidine SideEffects DuringPregnancyor Breastfeeding DrugInteractions Pricing&Coupons EnEspañol Drugclass:miscellaneousanxiolytics,sedativesandhypnotics LatestFDAAlerts(2) Consumerresources PatientInformation OtherbrandsPrecedex Professionalresources PrescribingInformation Relatedtreatmentguides Sedation FurtherinformationAlwaysconsultyourhealthcareprovidertoensuretheinformationdisplayedonthispageappliestoyourpersonalcircumstances. MedicalDisclaimer Subscribetoournewsletters News&warningsforthisdrug FDASafetyAlertsforallmedications DailyMedNews MonthlyNewsletter IaccepttheTermsandPrivacyPolicy Emailaddress Selectoneormorenewsletterstocontinue.