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Latest in Blood. Free Articles. Nonleukemic T/B mixed phenotype acute leukemia ... Oscar Silva; Jason Kurzer. DOI: 10.1182/blood.2021012538. SkiptoMainContent Advertisement Close BloodBloodAdvancesHematologyASH-SAPASHClinicalNewsTheHematologistASHNewsDailyInternationalBloodChineseEditionBloodJapaneseEditionBloodItalianEditionBloodLatinAmericaEditionBloodSpanishEditionASHASHHomeResearchEducationAdvocacyMeetingsPublicationsASHStore Cart UserTools Cart SignIn Search navsearch searchinput Searchinputautosuggest searchfilter AllContentAllJournalsBlood Search ToggleMenuMenu Issues CurrentIssue AllIssues Firstedition Abstracts 2020AnnualMeeting 2020LateBreaking 2019AnnualMeeting 2019LateBreaking 2018AnnualMeeting AllMeetingAbstracts Collections Collections SpecialCollections Multimedia Alerts AuthorCenter Submit AuthorGuide StyleGuide WhySubmittoBlood? About AboutBlood EditorialBoardandStaff Subscriptions PublicAccess Copyright Alerts BloodClassifieds SkipNavDestination CurrentIssue Volume138, Issue20, November18,2021 ViewThisIssue IssueHighlights RNAeditingandHSCdifferentiation Artificialintelligenceandbonemarrowcytology DanicopanpluseculizumabforPNH Tumor-suppressiveroleofmiR-497/195inALL CMEarticle:genomicsandtranscriptomicsofIgMmultiplemyeloma LatestinBlood FreeArticles NonleukemicT/BmixedphenotypeacuteleukemiawithPHF6andNOTCH1mutations OscarSilva;JasonKurzer DOI: 10.1182/blood.2021012538 ViewAllFreeArticles PlenaryPapers Highlyaccuratedifferentiationofbonemarrowcellmorphologiesusingdeepneuralnetworksonalargeimagedataset ChristianMatek;SebastianKrappe;ChristianMünzenmayer;TorstenHaferlach;CarstenMarr DOI: 10.1182/blood.2020010568 ViewAllPlenaryPapers FirstEdition SystemicIL-15promotesallogeneiccellrejectioninpatientstreatedwithnaturalkillercelladoptivetherapy MelissaMBerrien-Elliott;MichelleBecker-Hapak;AmandaF.Cashen;MiriamT.Jacobs;PamelaWong;MarkFoster;EthanMcClain;SwetaDesai;PatrickPence;SarahCooley;ClaudioGBrunstein;FengGao;CamilleNAbboud;GeoffreyL.Uy;PeterWestervelt;MeaganAJacoby;IskraPusic;KeithStockerl-Goldstein;MarkASchroeder;JohnFDiPersio;PatrickSoon-Shiong;JeffreyS.Miller;ToddAFehniger DOI: 10.1182/blood.2021011532 ViewAllFirstEditionArticles ClinicalTrialsandObservations Effectofibrutinibtreatmentonhemolyticanemiaandacrocyanosisincoldagglutinindisease/coldagglutininsyndrome MaritJalink;SigbjørnBerentsen;JorgeJ.Castillo;StevenP.Treon;MarjanCruijsen;BrunoFattizzo;RamonaCassin;DespinaFotiou;EfstathiosKastritis;MasjaDeHaas;LiesbethE.M.Oosten;HenrikFrederiksen;AndreaPatriarca;ShirleyD'Sa;JosephineM.I.Vos DOI: 10.1182/blood.2021012039 ViewAllClinicalTrialsandObservations Advertisement ASHStatementinSupportoftheValueofScholarlyPublishers   ASH'sCommitmenttoDiversity,Equity,andInclusioninHealthCare FeaturedContent Danicopanadd-ontherapyinPNH,neuralnetworkstoidentifybonemarrowcells,andRNAeditomeandhematopoiesis Inthisweek’sepisode,we’llreviewresultsofaphase2studyshowingthebeneficialeffectsofafirst-in-classfactorDinhibitorasadd-ontherapyinPNHpatientswhoremainanemicandaretransfusion-dependentdespiteC5inhibition.Next,we’llreviewtheworkofresearcherswhohavedevelopedaneuralnetworkthattheysayishighlyaccurateindifferentiatingbetweenbonemarrowcellmorphologies.We’llclosewithareportdemonstratingthatRNAeditingofantizymeinhibitor1,orAzin1,isanovelregulatorofhematopoieticcellfatethatcaninfluenceself-renewalanddifferentiation. Highlyaccuratedifferentiationofbonemarrowcellmorphologiesusingdeepneuralnetworksonalargeimagedataset Artificialintelligence(AI)andmachinelearningalgorithmsarechangingmanyfacetsofourlivesandhavegreatpotentialfordiseasediagnosis.InthisPlenaryPaper,Mateketaldescribetrainingaconvolutionalneuralnetworkmodelusing171374bonemarrowcytologyimagesfrom945patientswithvarioushematologicaldiseasesbeforevalidatingitsaccuracyinclassifyingsinglecellsinanindependentsetof627images.Thesystemcanautomaticallyclassify22classesofbonemarrowleukocytes,andwithfurtherimprovements,itmaybringAI-aideddiagnosisofbonemarrowbiopsyspecimensclosertofruition. Phase2studyofdanicopaninpatientswithparoxysmalnocturnalhemoglobinuriawithaninadequateresponsetoeculizumab Somepatientswithparoxysmalnocturnalhemoglobinuria(PNH)remainpersistentlyanemicdespitetreatmentwitheculizumabandmayhavesignificantextravascularhemolysis.Kulasekararajandcolleaguesreportaphase2trialofdanicopan,afirst-inclassoralcomplementfactorDinhibitor,addedtoongoingeculizumabtherapyinPNHpatientswhostillneededtransfusions.Thissmallstudyof12patientsrevealsthatthecombinationhasacceptablesafetywhilesubstantiallyincreasingthehemoglobinconcentration,reducingextravascularhemolysis,andimprovingthefatiguescore. AcomprehensiveRNAeditomerevealsthateditedAzin1partnerswithDDX1toenablehematopoieticstemcelldifferentiation WangetalprovideinsightintohowepigeneticregulationofthetranscriptomecanrewirecellfatedecisionsbymappingtheRNA-editinglandscapeduringhematopoiesis.Theyreportthatadenosine-to-inosineRNAeditingofantizymeinhibitor1(Azin1)isanovelregulatorofhematopoieticcellfate,capableofinfluencingself-renewalanddifferentiationofhematopoieticstemcells.ThisworksetsthescenefordevelopingRNAediting–targetedtherapeuticsforstemcellexpansionandmodulatingAZIN1-inducedcancerstemcellgeneration. MicroRNA-497/195istumorsuppressiveandcooperateswithCDKN2A/Binpediatricacutelymphoblasticleukemia Currentimprovementsintreatmentforchildrenwithacutelymphoblasticleukemia(ALL)arebasedondetailedmolecularclassificationthatinfluencesprognosisandcanguidetherapy.BoldrinetalidentifiedanovelbiomarkerofpooroutcomeinALL,and,usingcellandinvivomodels,theydelineatedthebiologicallinkbetweenmicroRNA-497/195repressionandmoreaggressivedisease.Theirresearchalsopointstoexploringpharmacologicalcellcycleinhibitionasapotentialmethodfortreatingthesehigh-riskleukemias. IgM-MMispredominantlyapre–germinalcenterdisorderandhasadistinctgenomicandtranscriptomicsignaturefromWM Inthismonth’sCMEarticle,BazarbachietaldescribethegenomiccharacterizationofimmunoglobulinM(IgM)multiplemyeloma(MM)andcontrastthisrareentitywiththefarmorecommonnon-IgMMMandWaldenströmmacroglobulinemia.TheirresultshelpexplainwhyIgM-MMisadistinctclinicalandbiologicalentityandhighlightspecificgeneticabnormalitiesandtranscriptomicfeatures.ThesefindingsprovidearationalbasisforthefutureexplorationofadditionaltargetedtherapiesbeyondthosetypicallyprescribedforMMingeneral. 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