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Anxiety link to irritable bowel syndrome seen in DNA - research

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Genes may go some way towards explaining why a common but poorly understood gut disorder - irritable bowel syndrome (IBS) - is often linked ... Imagesource,GettyImagesGenesmaygosomewaytowardsexplainingwhyacommonbutpoorlyunderstoodgutdisorder-irritablebowelsyndrome(IBS)-isoftenlinkedtoanxiety,sayresearchers.TheyhopetheirdiscoverywillstopIBSbeingwronglylabelledasanemotionalstateor"allinthemind".Theteamstudiedmorethan50,000individualswithIBS,comparingtheirDNAwiththatofhealthypeople.TheresultsarepublishedinthejournalNatureGenetics.IBSisthoughttoaffectaboutonein10peopleandcancausedistressingabdominalpain,bloatingandboutsofconstipation,diarrhoeaorboth.Withnodefiningtest,diagnosiscomesafterrulingoutothercauses.Womenareslightlymoreaffectedthanmen,andtheusualageforpatientstoseekadviceisbetween20and40.ProfMilesParkes,aconsultantgastroenterologistatCambridge'sAddenbrookesHospitalwholedthegeneresearch,saysIBSisstillpoorlyunderstood,evenbysomedoctors,andmaybeincorrectlycategorisedaspsychosomaticbecauseoftheoverlapwithanxietyandstress.Heandhisteamsaytheyhaveidentifiedatleastsixdistinctgeneticdifferencesthatmight,atleastpartly,explainthislinkbetweenthegutandthemind.Theresultsshowed:Overall,heritabilityofIBS(howmuchyourgenesinfluencethelikelihoodofdevelopingaparticularcondition)isquitelowSixgeneticdifferencesweremorecommoninpeoplewithIBSthanincontrolsMostofthesehaverolesinthebrain,andpossiblythenerveswhichsupplythegut,ratherthanthegutitselfThesamegeneticmake-upthatputspeopleatincreasedriskofIBSalsoincreasestheriskforcommonmoodandanxietydisorderssuchasanxiety,depression,andneuroticism,aswellasinsomniaThatdoesn'tmeananxietycausesIBSsymptomsorviceversa,saysProfParkes."Ourstudyshowstheseconditionshavesharedgeneticorigins,withtheaffectedgenespossiblyleadingtophysicalchangesinbrainornervecellsthatinturncausesymptomsinthebrainandsymptomsinthegut."ThediscoverymightultimatelyhelpwithdevelopingbettertestsandtreatmentsforIBS.Mediacaption,'There'sdefinitelyastigmaaroundhavingIBS'LauraTebbs,whois34andfromCambridge,hasexperiencelivingwithIBSsymptomsandanxietyanddepression."I'vehadboutsofdepressionandanxietyforadecadesoIknowwhatitisliketolivewiththat,butmyIBSbeganafterIcaughtCovidthisJanuary."It'shardforsomepeopletounderstand,butIBSreallyisquiteachallengingthingtolivewith."IwasinconstantpaineverytimeIate.AndI'dgetreallybloated.ItwassobadthatIcouldn'twearanyofmynormaltrousersorjeans.Ijustlivedinleggingsinstead."Iwastiredandmoodyandcouldn'tdothingsthatIwouldnormallyenjoy,likegoingoutforamealwithmates."Laurasaysshewas"fobbedoff"bysomehealthcareprofessionalswho,shesays,dismissedherconditionandrecommendedlaxativesforoneofhersymptoms-constipation.SheisnowunderProfParkes'scareandhasfoundwaystobettermanagehercondition."It'smuchbetternow,andifIdohaveaflare-upthereIthingsIcandotochangeit."IBStipsMedicationmaybeneeded,buttherearesomeotherthingsthatcanhelptoo.Imagesource,GettyImagesToeasebloating,crampsandwind,consider:Eatoats,suchasporridgeFreshingredients,ratherthanlotsofprocessed,fattyorspicyfoods,isgoodbutdon'toverdoitwiththefruitandbeansbecausetheycancausediarrhoeaandbloatingCauliflower,cabbage,sproutsandonionscanbetrickyforsomepeopletodigesttooYoucouldtryprobioticsorlowlactoseorlactose-freedairyproductsforamonthandseeiftheyhelpDon'tdelayorskipmealsAvoidlotsofalcohol,caffeineorfizzydrinks,butdodrinkplentyofwatertokeepyourpoonicelysoft(ratherthantoorunnyorhard)Taketimeovermeals-don'teattooquicklyForconstipation:DrinkplentyofwatertomakepoosofterEatfibre-linseeds,forexample,helpedLauraFordiarrhoea:ConsidercuttingbackabitonfibreifyouareeatinglotsofitChewinglotsofsugar-freegumcontainingsorbitolisanother"no-no"-itcanhavealaxativeeffectMakesureyouaredrinkingenoughfluidtoreplacewhatyouarelosingandavoiddehydrationSource:NHSRelatedTopicsCambridgeDiet&nutritionIrritablebowelsyndromeRelatedInternetLinksBritishDieteticAssociation(BDA)TheIBSNetworkBritishNutritionFoundationTheBBCisnotresponsibleforthecontentofexternalsites.TopStoriesIraqiPMsurvivesdroneattackonhishomeMustafaal-KadhimisayshewasnothurtintheattackbyadronecarryingexplosivesinBaghdad.Published51minutesagoPoliceinvestigatecrowdsurgeatTexasfestivalPublished4hoursagoRowoverattempttogroundLibya'sforeignministerPublished32minutesagoFeaturesLyseDoucet’slovelettertoKabulthroughninetreasuredplacesAswinterlooms,reportsofstarvationinNorthKoreaHowfreshisyourfood?Sensorscouldshowyou.VideoHowfreshisyourfood?SensorscouldshowyouInstagram:Ablessingoracurse?MakingtheBBC’sLifeat50Cseason.VideoMakingtheBBC’sLifeat50CseasonLongest-servingleaderintheAmericasstandsagainHenryLau:fromK-PoptoPopArt.VideoHenryLau:fromK-PoptoPopArtDefyingSudan'sgenerals:'Theycannotkillusall'WhywemarchedinGlasgowElsewhereontheBBCLyricsquizHaveyoubeengettingthesesongswrong?FeelinghotWhathappenstoyourbodyinextremeheat?MostRead1IraqiPMsurvivesdroneattackonhishome2FleeingpassengersshutdownbusySpanishairport3PoliceinvestigatecrowdsurgeatTexasfestival4USNavylaunchesshipnamedforgayrightsleader5UB40foundingmemberAstrodiesafterillness6Instagram:Ablessingoracurse?7RowoverattempttogroundLibya'sforeignminister8UScourthaltsBidenvaccinemandateforcompanies9Ex-PMcondemnsgovernment's'shameful'actio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